The Role of a Neurovascular Signaling Pathway Involving Hypoxia-Inducible Factor and Notch in the Function of the Central Nervous System
Seunghee Kim , Minjae Lee and Yoon Kyung Choi*
Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Republic of Korea
E-mail: ykchoi@konkuk.ac.kr
Tel: +82-2-450-0558, Fax: +82-2-444-3490

The first two authors contributed equally to this work.
Received: July 19, 2019; Revised: August 6, 2019; Accepted: August 12, 2019; Published online: September 5, 2019.
© The Korean Society of Applied Pharmacology. All rights reserved.

Abstract
In the neurovascular unit, the neuronal and vascular systems communicate with each other. O2 and nutrients, reaching endothelial cells (ECs) through the blood stream, spread into neighboring cells, such as neural stem cells, and neurons. The proper function of neural circuits in adults requires sufficient O2 and glucose for their metabolic demands through angiogenesis. In a central nervous system (CNS) injury, such as glioma, Parkinson’s disease, and Alzheimer’s disease, damaged ECs can contribute to tissue hypoxia and to the consequent disruption of neuronal functions and accelerated neurodegeneration. This review discusses the current evidence regarding the contribution of oxygen deprivation to CNS injury, with an emphasis on hypoxia-inducible factor (HIF)-mediated pathways and Notch signaling. Additionally, it focuses on adult neurological functions and angiogenesis, as well as pathological conditions in the CNS. Furthermore, the functional interplay between HIFs and Notch is demonstrated in pathophysiological conditions.
Keywords: Hypoxia-inducible factor, Notch signaling, Oxygen, Central nervous system


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