Niacinamide Protects Skin Cells from Oxidative Stress Induced by Particulate Matter
Ao Xuan Zhen1, Mei Jing Piao1, Kyoung Ah Kang1, Pincha Devage Sameera Madushan Fernando1, Hee Kyoung Kang1, Young Sang Koh1, Joo Mi Yi2 and Jin Won Hyun1,*
1Jeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju 63243, 2Department of Microbiology and Immunology, Inje University College of Medicine, Busan 47392, Republic of Korea
E-mail: jinwonh@jejunu.ac.kr Tel: +82-64-754-3838, Fax: +82-64-702-2687
Received: April 15, 2019; Revised: May 8, 2019; Accepted: June 7, 2019; Published online: July 5, 2019.
© The Korean Society of Applied Pharmacology. All rights reserved.

Abstract
Niacinamide (NIA) is a water-soluble vitamin that is widely used in the treatment of skin diseases. Moreover, NIA displays antioxidant effects and helps repair damaged DNA. Recent studies showed that particulate matter 2.5 (PM2.5) induced reactive oxygen species (ROS), causing disruption of DNA, lipids, and proteins; mitochondrial depolarization, and apoptosis of skin keratinocytes. Here, we investigated the protective effects of NIA on PM2.5-induced oxidative stress in human HaCaT keratinocytes. We found that NIA could inhibit the ROS generation induced by PM2.5, as well blocked the PM2.5-induced oxidation of molecules, such as lipids, proteins, and DNA. Furthermore, NIA alleviated PM2.5-induced accumulation of cellular Ca2+, which caused cell membrane depolarization and apoptosis, and reduced the number of apoptotic cells. Collectively, the findings show that NIA can protect keratinocytes from PM2.5-induced oxidative stress and cell damage.
Keywords: Niacinamide, Particulate matter 2.5, Oxidative stress, Human HaCaT keratinocyte


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