Biomol Ther  
4’-O-β-D-Glucosyl-5-O-Methylvisamminol Attenuates Pro-Inflammatory Responses and Protects against Oxidative Damage
Ok-Kyung Yoo and Young-Sam Keum*
Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University, Goyang 10326, Republic of Korea
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Received: December 12, 2018; Revised: February 17, 2019; Accepted: March 4, 2019; Published online: April 10, 2019.
© The Korean Society of Applied Pharmacology. All rights reserved.

We attempted to examine anti-inflammatory and anti-oxidant effects of 4’-O-β-D-glucosyl-5-O-methylvisamminol (GOMV), the first epigenetic inhibitor of histone phosphorylation at Ser10. While GOMV did not affect the viability of murine macrophage RAW 264.7 cells, it significantly suppressed lipopolysaccharide (LPS)-induced generation of prostaglandin E2 (PGE2) and nitric oxide (NO) through transcriptional inhibition of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). GOMV also scavenged free radicals in vitro, increased NF-E2-related factor 2 (NRF2), and activated antioxidant response element (ARE), thereby resulting in the induction of phase II cytoprotective enzymes in human keratinocyte HaCaT cells. Finally, GOMV significantly protected HaCaT cells against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative intracellular damages. Together, our results illustrate that GOMV possesses anti-inflammatory and anti-oxidant activity.
Keywords: 4’-O-β-D-glucosyl-5-O-methylvisamminol (GOMV), Reactive oxygen species (ROS), NF-E2-related factor 2 (NRF2), Antioxidant response element (ARE)

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