Biomol Ther  
Medicinal Herbs Effective Against Atherosclerosis: Classification According to Mechanism of Action
Jae-Yong Kim and Sang Hee Shim*
Colleage of Pharmacy, Duksung Woman’s University, Seoul 01369, Republic of Korea
E-mail: sangheeshim@duksung.ac.kr
Tel: +82-2-901-8774, Fax: +82-2-901-8386
Received: December 5, 2018; Revised: February 23, 2019; Accepted: February 27, 2019; Published online: March 26, 2019.
© The Korean Society of Applied Pharmacology. All rights reserved.

Abstract
Atherosclerosis is a widespread and chronic progressive arterial disease that has been regarded as one of the major causes of death worldwide. It is caused by the deposition of cholesterol, fats, and other substances in the tunica intima which leads to narrowing of the blood vessels, loss of elasticity, and arterial wall thickening, thus causing difficulty in blood flow. Natural products have been used as one of the most important strategies for the treatment and prevention of cardiovascular diseases for a long time. In recent decades, as interests in natural products including medicinal herbs have increased, many studies regarding natural compounds that are effective against atherosclerosis have been conducted. The purpose of this review is to provide a brief overview of the natural compounds that have been used for the treatment and prevention of atherosclerosis, and their mechanisms of action based on recent research.
Keywords: Atherosclerosis, Medicinal herb, Mechanism of action, Cholesterol


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