Decursinol Angelate Ameliorates Dextran Sodium Sulfate-Induced Colitis by Modulating Type 17 Helper T Cell Responses
Bikash Thapa1, Seongwon Pak2, Hyun-Joo Kwon3 and Keunwook Lee1,2,*
1Institute of Bioscience and Biotechnology and 2Department of Biomedical Science, Hallym University, Chuncheon 24252, 3Department of Microbiology, College of Medicine, Hallym University, Chuncheon 24252, Republic of Korea
Tel: +82-33-248-2113, Fax: +82-33-256-3420
Received: January 10, 2019; Revised: February 12, 2019; Accepted: February 20, 2019; Published online: March 25, 2019.
© The Korean Society of Applied Pharmacology. All rights reserved.

Angelica gigas has been used as a Korean traditional medicine for pain relief and gynecological health. Although the extracts are reported to have an anti-inflammatory property, the bioactive compounds of the herbal plant and the effect on T cell responses are unclear. In this study, we identified decursinol angelate (DA) as an immunomodulatory ingredient of A. gigas and demonstrated its suppressive effect on type 17 helper T (Th17) cell responses. Helper T cell culture experiments revealed that DA impeded the differentiation of Th17 cells and IL-17 production without affecting the survival and proliferation of CD4 T cells. By using a dextran sodium sulfate (DSS)-induced colitis model, we determined the therapeutic potential of DA for the treatment of ulcerative colitis. DA treatment attenuated the severity of colitis including a reduction in weight loss, colon shortening, and protection from colonic tissue damage induced by DSS administration. Intriguingly, Th17 cells concurrently with neutrophils in the colitis tissues were significantly decreased by the DA treatment. Overall, our experimental evidence reveals for the first time that DA is an anti-inflammatory compound to modulate inflammatory T cells, and suggests DA as a potential therapeutic agent to manage inflammatory conditions associated with Th17 cell responses.
Keywords: Angelica gigas, Decursinol angelate, Type 17 helper T cell, IL-17, Ulcerative colitis

This Article

Cited By Articles
  • CrossRef (0)