Biomol Ther  
Regulation of Neural Stem Cell Fate by Natural Products
Hyun-Jung Kim*
Laboratory of Molecular Stem Cell Pharmacology, College of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea
E-mail: hyunjungkim@cau.ac.kr
Tel: +82-2-820-5619, Fax: +82-2-820-5619
Received: September 27, 2018; Revised: October 22, 2018; Accepted: November 2, 2018; Published online: November 27, 2018.
© The Korean Society of Applied Pharmacology. All rights reserved.

Abstract
Neural stem cells (NSCs) can proliferate and differentiate into multiple cell types that constitute the nervous system. NSCs can be derived from developing fetuses, embryonic stem cells, or induced pluripotent stem cells. NSCs provide a good platform to screen drugs for neurodegenerative diseases and also have potential applications in regenerative medicine. Natural products have long been used as compounds to develop new drugs. In this review, natural products that control NSC fate and induce their differentiation into neurons or glia are discussed. These phytochemicals enable promising advances to be made in the treatment of neurodegenerative diseases.
Keywords: Neural stem cells, Cell fate, Neurogenesis, Differentiation, Antioxidative, Neuroprotection


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