Biomolecules & Therapeutics 2009; 17(3): 270-275  
Attenuated Cerebral Ischemic Injury by Polyethylene Glycol-Conjugated Hemoglobin
Geum-Sil CHO1, In-Young CHOI1, Yoo Keum CHOI1, Seul-Ki KIM1, Ying CAI1, Kwang NHO2, and Jae-Chul LEE3,*
1Department of Neuroscience, College of Medicine, Korea University, Seoul 136-705, 2SunBio Inc., Anyang 431-060, 3Clinical Research Institute, Seoul National University Hospital, Seoul 110-744, Republic of Korea
Jae-Chul LEE
Received: May 25, 2009; Revised: May 28, 2009; Accepted: May 29, 2009; Published online: July 31, 2009.
© The Korean Society of Applied Pharmacology. All rights reserved.

Abstract
Polyethylene glycol-conjugated hemoglobin (PEG-Hb) has been proposed as a blood substitute for transfusion due to their plasma expansion and oxygen transport capabilities. The protective effect of PEG-Hb on cerebral hypoxic-ischemic injury was investigated in neonatal hypoxia model and adult rat focal cerebral ischemia model. As intravenously administered 30 min before the onset of hypoxia, PEG-Hb markedly protected cerebral hypoxic injury in a neonatal rat hypoxia model. A similar treatment of PEG-Hb largely reduced the ischemic injury ensuing after 2-h middle cerebral artery occlusion followed by 22-h reperfusion. Consistently, neurological disorder was significantly improved by PEG-Hb. The results indicate that the pharmacological blockade of cerebral ischemic injury by using PEG-Hb may provide a useful strategy for the treatment of cerebral stroke.
Keywords: Polyethylene glycol-conjugated hemoglobin, Hypoxia, Focal cerebral ischemia


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