Interplay Between Primary Cilia and Autophagy and Its Controversial Roles in Cancer
Je Yeong Ko, Eun Ji Lee and Jong Hoon Park*
Department of Life Systems, Sookmyung Women’s University, Seoul 04310, Republic of Korea
Tel: +82-2-710-9414, Fax: +82-2-2077-7258
The first two authors contributed equally to this work.
Received: March 29, 2019; Revised: April 3, 2019; Accepted: April 5, 2019; Published online: May 2, 2019.
© The Korean Society of Applied Pharmacology. All rights reserved.

Primary cilia and autophagy are two distinct nutrient-sensing machineries required for maintaining intracellular energy homeostasis, either via signal transduction or recycling of macromolecules from cargo breakdown, respectively. Potential correlations between primary cilia and autophagy have been recently suggested and their relationship may increase our understanding of the pathogenesis of human diseases, including ciliopathies and cancer. In this review, we cover the current issues concerning the bidirectional interaction between primary cilia and autophagy and discuss its role in cancer with cilia defect.
Keywords: Cilia, Autophagy, Ciliopathy, Cancer

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