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Fig. 6. Effect of azole antifungal compounds on protein expression. MCF-7 and MDA-MB-231 cells were treated with 50 μM imidazole [clotrimazole (CTZ) or ketoconazole (KCZ)] or triazole [fluconazole (FCZ) or itraconazole (ICZ)] compounds for 24 h. The protein expression related to apoptosis (A) and cell cycle (B) were examined in MCF-7 and MDA-MB-231 cells after treatment of each compound for 24 h. The protein expression was also examined in the xenograft model of MDA-MB-231 cells after treatment of each compound for 8 weeks (C). Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) was used as the loading control. This experiment was performed three times. Band density was estimated using ImageJ 1.45s software (NIH).
Biomolecules & Therapeutics 2018;26:494~502 https://doi.org/10.4062/biomolther.2018.042
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