Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

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Fig. 4. Principle of the selective inhibition of nuclear factor E2-related factor 2 (NRF2) using selective glucocorticoid receptor agonists and modulators (SEGRAM). (A) The mechanisms of classic GCs on gene expression and NRF2 inhibition. Once binding to GR, GC regulates gene expression via both transactivation and transrepression of diverse genes involved in immunosuppression and hyperglycemia. (B) The proposed mechanisms of SEGRAMs on selective inhibition of NRF2. Although SEGRAMs can bind to GR, it may not be sufficient to induce transactivation or transrepression but sufficient to induce NRF2 inhibition.
Biomolecules & Therapeutics 2018;26:57~68
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