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Fig. 2. Seven mechanisms of nuclear factor E2-related factor 2 (NRF2) activation in cancer. (1) Genetic mutations, (2) Epigenetic modifications, (3) KEAP1-NRF2 disruption, (4) Oncogenic signaling, (5) Stress signaling, (6) RNA processing, (7) Hormonal activation.
Biomolecules & Therapeutics 2018;26:57~68 https://doi.org/10.4062/biomolther.2017.195
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