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Fig. 1. Diagram of central metabolic pathways involved in cell growth and proliferation. Ac-CoA: acetyl-CoA, ACYL: ATP citrate lyase, ARG: arginase 1, ASL: argininosuccinate lyase, ASS1: argininosuccinate synthase 1, CAD: carbamoyl-phosphate synthase, GLS: glutaminase, GLUD: glutamate dehydrogenase 1, GOT2: glutamic-oxaloacetic transaminase or aspartate aminotransferase, HK2: hexokinase 2, LDHA: lactate dehydrogenase A, PFK: phosphofructokinase, PK: pyruvate kinase, SHMT1/2: serine hydroxymethyltransferase 1/2, SLC1A5: solute carrier family 1 member 5 or sodium-dependent neutral amino acid transporter type 2, SLC2A1: solute carrier family 2 member 1 or glucose transporter1 (GLUT-1).
Biomolecules & Therapeutics 2018;26:4~9 https://doi.org/10.4062/biomolther.2017.194
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