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Fig. 3. Effects of flavonoids on disaggregation of preformed Aβ1–42 fibrils. Preformed Aβ1–42 fibrils (20 μM) were incubated with ThT (5 μM) various concentrations of test compounds. The fluorescent intensity of ThT-Aβ fibrils were measured every 2.5 min using a plate reader. (A) Time-course of disaggregation of Aβ1–42 fibrils in the presence of various concentrations of amentoflavone. (B) Concentration-dependent disaggregating effects of the test compounds on Aβ1–42 fibrils were plotted.
Biomolecules & Therapeutics 2020;28:145~151 https://doi.org/10.4062/biomolther.2019.113
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