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Fig. 4. Effects of GABAAR antagonist on the changes in sleep latency (A) and sleep duration (B) in mice treated with luteolin. Mice were injected with pentobarbital (i.p.) 30 min after oral administration (p.o.) of CTL (saline), DZP (1 mg/kg) or luteolin (3 mg/kg). Vehicle (saline), flumazenil (5 mg/kg, p.o.), or bicuculine (2 mg/kg, p.o.) was administered 15 min before luteolin administration. Each column represents mean ± SEM (n=6). *p<0.05, significant as compared to the control group. #p<0.05, significant as compared to each vehicle group. B, bicuculline; CTL, control; DZP, diazepam; F, flumazenil; Veh, vehicle.
Biomolecules & Therapeutics 2019;27:584~590 https://doi.org/10.4062/biomolther.2019.149
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