Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

Download original image
Fig. 4. Positions of mutated amino acid residues of variants in P450 2C9 structural model. (A) Overall structure of P450 2C9, (B) Structure of the substrate-binding site. The molecular structural model of P450 2C9 was constructed using the X-ray crystal structure of human P450 2C9 with bound warfarin (PDB ID: 1OG5). The P450 2C9 structural model and mutation sites were constructed using the PyMOL software (DeLano Scientific, South San Francisco, CA, USA).
Biomolecules & Therapeutics 2019;27:577~583 https://doi.org/10.4062/biomolther.2019.112
© Biomolecules & Therapeutics