Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

Download original image
Fig. 2. LC-MS/MS analysis of diclofenac hydroxylation by P450 2C9. (A) Chromatogram and fragmentation of diclofenac in the multiple reaction mode (MRM), (B) Chromatogram and fragmentation of 4-hydroxydiclofenac in the MRM. The transitions of the 4-hydroxydiclofenac-H+ adduct (m/z 314.15>231.15) and the diclofenac-H+ adduct (m/z 296>214) were monitored.
Biomolecules & Therapeutics 2019;27:577~583 https://doi.org/10.4062/biomolther.2019.112
© Biomolecules & Therapeutics