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Fig. 5. Effects of AUY954 on phosphorylation of Akt and MAPKs in post-ischemic brain. Mice were challenged with tMCAO. AUY954 (AUY, 5 mg/kg, p.o.) was then administered immediately after reperfusion. (A) Expression levels of p-Akt, Akt, p-ERK1/2, ERK1/2, p-p38, p38, p-JNK, JNK, and GAPDH proteins were assessed in the brain by Western blot analysis at 1 day after tMCAO challenge. (B) Quantifications. n=4 mice per group. *p<0.05, **p<0.01, and ***p<0.001 versus sham group. #p<0.05 and ###p<0.001 versus vehicle-administered tMCAO mice (tMCAO+veh).
Biomolecules & Therapeutics 2019;27:522~529 https://doi.org/10.4062/biomolther.2019.005
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