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Fig. 2. Effects of AUY954 on mRNA expression levels of M1 soluble markers in post-ischemic brain. Mice were challenged with tMCAO. AUY954 (AUY, 5 mg/kg, p.o.) was then administered immediately after reperfusion. Expression levels of TNF-α, IL-6, and IL-1β mRNAs were assessed in the brain through qRT-PCR analysis at 1 day (A–C) and 3 days (D–F) after tMCAO challenge. n=4–5 mice per group. *p<0.05, **p<0.01 and ***p<0.001 versus sham group. #p<0.05, ##p<0.01, and ###p<0.001 versus vehicle-administered tMCAO mice (tMCAO+veh).
Biomolecules & Therapeutics 2019;27:522~529
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