Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

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Fig. 1. Overview of pathophysiology and management of osteoarthritis and strategy for the development of a promising pharmacological tool. The onset and progression of osteoarthritis, a chronic degenerative articular disorder, are attributed to various inflammatory cytokines in joint tissues and fluids that are produced by chondrocytes and/or interact with chondrocytes, as well as to low-grade inflammation in intraarticular tissues. Disruption of the equilibrium between synthesis and degradation of the cartilage of the joint is the major cause of osteoarthritis. Developing a promising pharmacological tool to restore the equilibrium between synthesis and degradation of osteoarthritic joint cartilage can be a useful strategy for the effective management of osteoarthritis.
Biomolecules & Therapeutics 2019;27:503~513
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