Fig. 4. Effect of poncirin on sRANKL-induced c-Fos and NFATc1 expression in RAW264.7 cells. Cells were pretreated with the indicated concentration of poncirin, after which they were cultured with sRANKL (100 ng/mL) for 4 days. The mRNA levels of c-Fos and NFATc1 were evaluated by quantitative real-time PCR. Fold changes relative to each gene level in the control are presented as mean ± SD of independent experiments (n=3). #p<0.05, ##p<0.01 compared with the control. *p<0.05, **p<0.01 compared with sRANKL.
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