Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

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Fig. 5. DA attenuates the activation of Th17 cells and the recruitment of neutrophils in the colitis tissues. (A) Mice were administered with DSS as in , and leukocytes isolate from the mesenteric lymph node (MLN), colonic intraepithelium (colonic IE) and lamina propria (colonic LP) were analyzed by intracellular cytokine staining. Shown are the representative FACS profiles with the inset numbers indicating the prevalence of the IL-17+ and/or IFN-γ+ cells in the live CD4 T cell gate. The mean (± SD) percentages of the IL-17A+ cells were calculated from two independent experiments, each involving four mice. (B) Infiltration of granulocyte populations in the colonic tissues were analyzed by flow cytometry. Shown are the representative FACS profiles in the live leukocyte gate and mean (± SD) prevalence of CD11bhi Gr-1hi. *p<0.05, **p<0.01.
Biomol Ther 2019;27:466~473 https://doi.org/10.4062/biomolther.2019.004
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