Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

Download original image
Fig. 7. Neuroprotective effects of AA on MPP+-induced cell damage. (A) Dose-dependent toxic effects of MPP+ on viability of SH-SY5Y cells. (B) SH-SY5Y cells were treated with AA and assessed using the MTT assay. (C) SH-SY5Y cells were pre-treated with AA for 24 h before being treated for 24 h with or without 300 μM MPP+ and assessed using the MTT assay. (D) SH-SY5Y cells were pre-treated with AA for 24 h before being treated for 24 h with or without medium supernatant from BV2 microglia cells that were treated with LPS for 24 h. The SH-SY5Y cells were then transferred into fresh medium and assessed using MTT assay. (E) SH-SY5Y cells were treated with medium supernatant from BV2 microglia cells that were pre-treated with AA (1.0 and 10 nM) for 24 h; 10 μg/mL LPS was then added for 24 h and assessed using MTT assay. Data are expressed as mean ± SD, analyzed by one-way ANOVA, ##p<0.01 compared to the control group; *p<0.05 and **p<0.01 compared to the model group.
Biomol Ther 2019;27:442~449 https://doi.org/10.4062/biomolther.2018.188
© Biomolecules & Therapeutics