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Fig. 5. Comparison of the time course of decrease in calcium signal at different capsaicin concentrations with fixed ratios of antagonist to capsaicin. Capsaicin at 100 nM, 300 nM, and 1,000 nM was added simultaneously with the indicated ratios of antagonist to capsaicin (expressed ratio values rounded to one significant figure). The initial calcium response and that after 100 s and 500 s are plotted. BCTC represents an antagonist with an apparent intermediate rate of penetration. Note the partial inhibition at T=0 at the highest ratio of antagonist to capsaicin. Values at 100 nM and 300 nM represent the mean ± SE of triplicate experiments. Values at 1,000 nM represent the mean ± SE for the data within the single experiment. Note that the time scale is shifted relative to that in .
Biomol Ther 2019;27:435~441 https://doi.org/10.4062/biomolther.2019.013
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