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Fig. 1. Development of methamphetamine-induced sensitization and postsynaptic dopamine receptor supersensitivity. Locomotor activity was measured after (A) methamphetamine (1 mg/kg, i.p.) and (B) apomorphine (0.5 mg/kg, i.p.) injections in vehicle (distilled water)- or methamphetamine-pretreated (1 or 5 mg/kg) rats. Values indicate the mean ± standard error (SE) (n=8). *p<0.05 vs. vehicle/saline, #p<0.05 vs. vehicle/METH 1 mg/kg (one-way ANOVA, followed by Bonferroni’s test). METH, methamphetamine; APO, apomorphine.
Biomol Ther 2019;27:357~362 https://doi.org/10.4062/biomolther.2018.213
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