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Fig. 4. The expression levels of synaptophysin in 5XFAD mice. Western blot analysis was conducted 12 weeks after the Theracurmin administration. The expression levels of synaptophysin were measured in the cortex (A) and the hippocampus (B). The last administration of Theracurmin (100, 300 or 1,000 mg/kg) or vehicle solution was performed 1 h before sacrifice. The decreased expression levels of synaptophysin, a pre-synaptic vesicle protein, in 5XFAD mice were reversed by Theracurmin administration. Immunoreactivity was normalized to controls is presented as mean ± SEM (n=5–6/group). *p<0.05, **p<0.01 when compared to the control group; #p<0.05, ##p<0.01 when compared to the vehicle-treated group.
Biomol Ther 2019;27:327~335 https://doi.org/10.4062/biomolther.2019.046
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