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Fig. 6. Effect of JTE-013 on TGF-β1-induced ECM expression and EMT in A549 cells. Expression of ECM and EMT associated proteins (collagen Iα1, N-cadherin, fibronectin, E-cadherin, and ZEB1) confirmed in A549 cells by RT-PCR analysis. A549 cells were cultured for 24 h in media containing 0.5% FBS and then treated with JTE-013 and TGF-β1 for 24 h. mRNA levels were expressed as ratios with GAPDH mRNA levels. The values shown are mean ± SE (n=3). Statistical significance: ***p<0.001 vs. vehicle-treated cells and #p<0.05, ##p<0.01, ###p<0.001 vs. TGF-β1-treated cells.
Biomolecules & Therapeutics 2019;27:318~326
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