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Fig. 3. Inhibitory effect of S1P2 deficiency on fibrosis in lung. Bleomycin or saline was administered intratracheally to S1P2 WT and KO mice. Twenty-eight days after bleomycin instillation, histological analysis in lungs was performed by H&E staining (A) and Masson’s trichrome staining (B). The amounts of hydroxyproline in lung tissues from PBS- or bleomycin-treated mice were analyzed as quantitation of collagen (C). The values shown are mean ± SE (n = 6). Statistical significance: ***p<0.001 vs. PBS-treated S1P2 WT mice, #p<0.05 vs. PBS-treated S1P2 KO mice, and †††p<0.001 vs. bleomycin-treated S1P2 WT mice.
Biomol Ther 2019;27:318~326
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