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Fig. 2. Suppressive effect of S1P2 deficiency on mRNA expression of pro-inflammatory cytokines in BALF or lung tissues. (A, B) RT-PCR analysis of pro-inflammatory cytokines (IL-1β, IL-6, TNFα, and MCP-1) was performed using mRNA in BALF-associated cells on the 7th day after bleomycin treatment. (C, D) mRNA expression of pro-inflammatory cytokines was checked by RT-PCR using mRNAs isolated from lung tissues. mRNA levels were expressed as ratios with GAPDH mRNA levels. The values shown are mean ± SE (n=6). Statistical significance: ***p<0.001 vs. PBS-treated S1P2 WT mice, #p<0.05, ###p<0.001 vs. PBS-treated S1P2 KO mice, and ††p<0.01, †††p<0.001 vs. bleomycin-treated S1P2 WT mice.
Biomol Ther 2019;27:318~326 https://doi.org/10.4062/biomolther.2018.131
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