Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

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Fig. 2. Pathway and Gene ontology (GO) analysis of DEGs common between two BRAF inhibitor-resistant cells. (A) Venn diagram showing unique as well as common DEGs in A375P/Mdr and SK-MEL-2 cells as compared to A375P cells. (B) Ten significant pathways associated with DEGs common in BRAF inhibitor-resistant cells. Significant DEGs with a log2 fold change ≥1 were analyzed for enriched biological processes using the ClueGO application for Cytoscape. The vertical axis represents the pathway category, and the horizontal axis represents the −log2 (p-value) of the pathways. Greater −log2 (p-value) scores correlate with increased statistical significance.
Biomol Ther 2019;27:302~310
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