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Fig. 6. A comparison of inhibitory effect and lipophilicity. (A) Relative inhibition of VD on rat brain and (B) relative inhibition on TR-BBB cells were compared for compounds with different lipophilicity. The relative inhibition [100-relative uptake (%)] was calculated based on the value listed in and . Compounds were classified as group I [closed circles: primary, secondary, tertiary amines, and closed star (paeonol and imperatorin)], group II (open squares: quaternary ammonium cations, group III (open circles: PAH and estron-3-sulfate), and organic anion substrates (OAT3 and Oatps). The regression lines of these groups are described by and in panels (A) and (B), respectively.
Biomol Ther 2019;27:290~301 https://doi.org/10.4062/biomolther.2019.007
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