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Fig. 5. Effect of OCTN2 siRNA on uptake of [3H]ALC and [3H]paeonol (A) and the effect of rPMAT siRNA on uptake of [3H]MPP+ and [3H] paeonol (B) by TR-BBB cells. Cells were transfected with negative control, OCTN2 siRNA, or rPMAT siRNA using Lipofectamine 2000 transfection reagent. After 2 days of transfection, the uptakes of [3H]ALC and [3H]MPP+ were measured at 15 min and the uptake of [3H]paeonol was measured at 37°C for 5 min. Each point represents mean ± SEM of three or four determinations at pH 7.4. **p<0.01 compared to the control.
Biomolecules & Therapeutics 2019;27:290~301 https://doi.org/10.4062/biomolther.2019.007
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