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Fig. 5. The effects of justicidin A on Aβ secretion were prevented by endocytosis inhibitors. (A, B) Cells were incubated with or without 0.5 µM justicidin A containing 150 µM dynasore for 2 h. The effects of justicidin A on Aβ42 (A, n=5) and Aβ40 (B, n=4) were blocked by a selective dynamin inhibitor, dynasore. (C, D) Cells were incubated with or without 0.5 µM justicidin A containing 20 µM chlorpromazine (CPZ), the clathrin-mediated endocytosis inhibitor, for 1 h. The effects of justicidin A on Aβ42 (C, n=7) and Aβ40 (D, n=6) were blocked by the presence of CPZ. ***p<0.001.
Biomolecules & Therapeutics 2019;27:276~282 https://doi.org/10.4062/biomolther.2018.112
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