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Fig. 3. Justicidin A increased the level of cell surface APP. (A) Upper panel. Cells were incubated with indicated concentrations of justicidin A for 4 h, and lysates were obtained for the detection of APP levels. β-tubulin was used to confirm the amount of proteins loaded. Lower panel. Cell surface APP level was measured using biotinylation method. The positions of maAPP and imAPP were indicated. (B) Bars indicate the levels of maAPP and imAPP obtained from densitometric analysis of Western bands in the upper panel in (A) (n=4). (C) Densitometric analysis of Western bands in the lower panel in (A) shows that justicidin A increased the cell surface maAPP level (n=4). *p<0.05.
Biomolecules & Therapeutics 2019;27:276~282 https://doi.org/10.4062/biomolther.2018.112
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