Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

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Fig. 4. Effects of flavonoids on signaling pathway of NLRP3 inflammasome activation. Many flavonoids possess anti-inflammatory activities by interrupting various signaling stages of NLRP3 inflammasome pathway both in vitro and in vivo. They inhibit the expression of NLRP3 inflammasome-related components such as IL-1β, IL-18, NLRP3, and caspase-1 and/or block inflammasome assembly which are mediated through signaling molecules such as TLR4/NF-κB/NLRP3, PPARγ, TXNIP and Syk/Pyk2, etc.
Biomol Ther 2019;27:241~253 https://doi.org/10.4062/biomolther.2019.034
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