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Fig. 3. Administration of 6-shogaol or 6-paradol reduces astrogliosis in spinal cords of EAE mice. Effects of 6-shogaol (Shog) and 6-paradol (Para) on astrogliosis were examined by GFAP immunolabeling (green). Sections were counterstained with DAPI (blue). (A) Representative images of GFAP immunoreactivity in the lumbar spinal cord of each group. (B) Quantification of fluorescence intensity (a.u., artificial unit). Scale bar, 100 μm. n=4 per group. **p<0.01 and ##p<0.01 vs. naïve and the vehicle-treated group, respectively, by Newman-Keuls multiple range test.
Biomolecules & Therapeutics 2019;27:152~159
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