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Fig. 2. Administration of 6-shogaol or 6-paradol reduces demyelination and cell accumulation in spinal cords of EAE mice. (A, B) Effects of 6-shogaol (Shog) and 6-paradol (Para) on demyelination were examined by FluoroMyelin staining (green). Sections were counterstained with DAPI (blue). Representative images of FluoroMyelin-stained lumbar spinal cord of each group (A) and quantification of FluoroMyelin intensity (B; a.u., artificial unit). (C, D) Effects of 6-shogaol and 6-paradol on increased cell density were examined by cresyl violet (CV) staining. Representative images of CV-stained lumbar spinal cord of each group (C) and quantification by counting the number of CV-stained cells (D). Scale bars, 100 μm. n=4 per group. ***p<0.001 vs. naïve. ##p<0.01 and ###p<0.001 vs. the vehicle-treated group. Newman-Keuls multiple range test.
Biomolecules & Therapeutics 2019;27:152~159 https://doi.org/10.4062/biomolther.2018.089
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