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Fig. 6. PD-1 expression on MDSCs is most likely regulated through NF-κB signaling pathway. (A–E) The CD11b+ cells were cultured in fresh medium in the presence of 10 ng/ml GM-CSF and then pre-treated with the indicated dose of BAY 11-7082. Next, the cells were treated with LPS (A, B) or TCCM (C–E). They were collected on day 4 for cell analysis. (C) For western blotting, cells were pre-treated with BAY 11-7082 and then TCCM was administered for 3 h. The experiments were independently performed at least 3 times. *p<0.05, **p<0.01, ***p<0.001.
Biomolecules & Therapeutics 2019;27:63~70
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